![]() These approaches include paired recordings, determination of syncytial isopotentiality, tracer coupling followed by analysis of network topography, and wide field imaging of ion sensitive dyes. Here, we describe different approaches to analyze gap junctional communication in acute tissue slices that can be implemented easily in most electrophysiology and imaging laboratories. However, these networks are not uniform but exhibit a brain region-dependent heterogeneous connectivity influencing electrical communication and intercellular ion spread. ![]() Panglial networks constitute on connexin-based gap junctions in the membranes of neighboring cells that allow the passage of ions, metabolites, and currents. These functions are fostered by the formation of large syncytia in which mainly astrocytes and oligodendrocytes are directly coupled. ![]() 2Department of Neuroscience, Wexner Medical Center, Ohio State University, Columbus, OH, United StatesĪstrocytes and oligodendrocytes are main players in the brain to ensure ion and neurotransmitter homeostasis, metabolic supply, and fast action potential propagation in axons.1Institute of Neurobiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.Jonathan Stephan 1*, Sara Eitelmann 1 and Min Zhou 2*
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